HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2090262Generated: October 30, 2026
Acetyl chloride → Methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)acetamido)methyl)phenyl)acetate
https://huagongshe.com/reaction/2090262
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Methyl 2-(4-((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propylamino)methyl)phenyl)acetate | HCID 25106601 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)acetamido)methyl)phenyl)acetate | HCID 59563513 | — |
Reaction Steps
The product from example 1 (142 mg) was dissolved in DCM (5 mL) and TEA (0.065 mL) was added. The reaction mixture was cooled to 0° C. Acetyl chloride (0.029 mL) was added and the reaction mixture stirred for 30 min. The solvents were evaporated and the residue was taken up in MeOH and purified by RPHPLC to afford the title compound (40 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08436178B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-9ac6292cbc7d4d809839eb0e502529de |
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| Source note | uspto-grants-2013_05 |
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