HRID2090291

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN1CCN(c2cc(N3CCc4ccc(Br)cc4C3)nc(N)n2)CC1

HCID46701048

未命名化合物

结构：CCOc1ccc(Cn2cc(B3OC(C)(C)C(C)(C)O3)cn2)cn1

HCID59402339

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(Cn2cc(-c3ccc4c(c3)CN(c3cc(N5CCN(C)CC5)nc(N)n3)CC4)cn2)cn1

HCID46701186

未命名化合物

PROCEDURE

实验过程

This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and 2-ethoxy-5-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}pyridine. LCMS(M+H)+: m/z=526.4

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ad29489bd5bd4164826f4e897c54a7b3
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436008B2
来源说明: uspto-grants-2013_05

反应 SMILES

Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([C:12]3[CH:17]=[C:16]([N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)[N:15]=[C:14]([NH2:25])[N:13]=3)[CH2:9]2)=[CH:4][CH:3]=1.[CH2:26]([O:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][N:36]2[CH:40]=[C:39](B3OC(C)(C)C(C)(C)O3)[CH:38]=[N:37]2)=[CH:31][N:30]=1)[CH3:27]>>[CH2:26]([O:28][C:29]1[N:30]=[CH:31][C:32]([CH2:35][N:36]2[CH:40]=[C:39]([C:2]3[CH:11]=[C:10]4[C:5]([CH2:6][CH2:7][N:8]([C:12]5[CH:17]=[C:16]([N:18]6[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]6)[N:15]=[C:14]([NH2:25])[N:13]=5)[CH2:9]4)=[CH:4][CH:3]=3)[CH:38]=[N:37]2)=[CH:33][CH:34]=1)[CH3:27]