4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine → HCID 46701187, compound

HRID 2090293Notes

Reaction equation

HRID 2090293 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([C:12]3[CH:17]=[C:16]([N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)[N:15]=[C:14]([NH2:25])[N:13]=3)[CH2:9]2)=[CH:4][CH:3]=1.CC1(C)C(C)(C)OB([C:34]2[CH:35]=[N:36][N:37]([C:39]3([CH2:44][C:45]#[N:46])[CH2:43][CH2:42][CH2:41][CH2:40]3)[CH:38]=2)O1>>[NH2:25][C:14]1[N:13]=[C:12]([N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][C:2]([C:34]4[CH:35]=[N:36][N:37]([C:39]5([CH2:44][C:45]#[N:46])[CH2:43][CH2:42][CH2:41][CH2:40]5)[CH:38]=4)=[CH:3][CH:4]=3)[CH2:9]2)[CH:17]=[C:16]([N:18]2[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]2)[N:15]=1

Participants

3

Reactant 2

HCID 467010484-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amineHCID 59402390HCID 59402390, compound

Product 1

HCID 46701187HCID 46701187, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and {1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]cyclopentyl}acetonitrile. LCMS(M+H)+: m/z=498.5

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-81d672a8d4b64738a56b51f3337e0b3e
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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