Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | [(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol | HCID 776757 | — |
| Reactant | 4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine | HCID 1484519 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 46701253 | HCID 46701253 | — |
Reaction Steps
A mixture of 4-chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine (20 mg, 87.8 mmol), (3 S)-1,2,3,4-tetrahydroisoquinolin-3-ylmethanol (21.5 mg, 132 mmol, Aldrich, Cat. 494186) and triethylamine (0.5 mL, 4 mmol) in N-methylpyrrolidinone (1 mL) was heated at 120° C. overnight. The reaction mixture was diluted in MeOH, and purified by RP-HPLC (pH=10) to afford the desired compound. LCMS (M+H)+: m/z=355.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08436008B2 |
|---|
| Source dataset | uspto-grants-2013_05 |
|---|
| ORD ID | ord-8904c5c4867644418f42fe07594f247a |
|---|
| Source note | uspto-grants-2013_05 |
|---|
