HCID 59402358, compound → HCID 178480765, compound

HRID 2090304Notes

Reaction equation

HRID 2090304 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:18]4[CH:19]=[CH:20][C:21]([C:24](O)=[O:25])=[N:22][CH:23]=4)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)[N:3]=1.[NH2:34][C@H:35]1[CH2:40][CH2:39][C@H:38]([OH:41])[CH2:37][CH2:36]1>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:18]4[CH:19]=[CH:20][C:21]([C:24]([NH:34][C@H:35]5[CH2:40][CH2:39][C@H:38]([OH:41])[CH2:37][CH2:36]5)=[O:25])=[N:22][CH:23]=4)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:27]2[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]2)[N:3]=1

Participants

3

Reactant 2

HCID 59402358HCID 59402358, compoundHCID 178511715HCID 178511715, compound

Product 1

HCID 178480765HCID 178480765, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 18 starting from 5-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinolin-7-yl}pyridine-2-carboxylic acid and trans-4-aminocyclohexanol (Acros Organics, Cat. 34668). LCMS (M+H)+: m/z=543.4.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-c6574a2af05247d68ccb1c40c2bd4d6f
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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