3-Phenylpyrrolidine → 4-(4-methylpiperazin-1-yl)-6-[7-[(3-phenylpyrrolidin-1-yl)carbonyl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

HRID 2090311Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2090311
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:18]([OH:20])=O)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:21]2[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]2)[N:3]=1.[C:28]1([CH:34]2[CH2:38][CH2:37][NH:36][CH2:35]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH3:27][N:24]1[CH2:23][CH2:22][N:21]([C:4]2[CH:5]=[C:6]([N:8]3[CH2:17][CH2:16][C:15]4[C:10](=[CH:11][C:12]([C:18]([N:36]5[CH2:37][CH2:38][CH:34]([C:28]6[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=6)[CH2:35]5)=[O:20])=[CH:13][CH:14]=4)[CH2:9]3)[N:7]=[C:2]([NH2:1])[N:3]=2)[CH2:26][CH2:25]1

Komponenten

3

Edukt 2

HCID 31467433-PhenylpyrrolidineHCID 594022702-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

Produkt 1

HCID 467013224-(4-methylpiperazin-1-yl)-6-[7-[(3-phenylpyrrolidin-1-yl)carbonyl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

Versuchsvorschrift

This compound was prepared by using procedures analogous to those described for the synthesis of Example 18 starting from 2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid and 3-Phenyl-pyrrolidine (Matrix Scientific, Cat. No. 018619).

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-fb35c38688e149d29d3c62b9107bb294
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436008B2

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