1-(2-Furoyl)piperazine → 4-{7-[4-(2-Furoyl)piperazin-1-yl]-3,4-dihydroisoquinolin-2(1H)-yl}-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

HRID 2090317Notes

Reaction equation

HRID 2090317 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([C:12]3[CH:17]=[C:16]([N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)[N:15]=[C:14]([NH2:25])[N:13]=3)[CH2:9]2)=[CH:4][CH:3]=1.[O:26]1[CH:30]=[CH:29][CH:28]=[C:27]1[C:31]([N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)=[O:32]>>[O:26]1[CH:30]=[CH:29][CH:28]=[C:27]1[C:31]([N:33]1[CH2:34][CH2:35][N:36]([C:2]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][N:8]([C:12]4[CH:17]=[C:16]([N:18]5[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]5)[N:15]=[C:14]([NH2:25])[N:13]=4)[CH2:9]3)=[CH:4][CH:3]=2)[CH2:37][CH2:38]1)=[O:32]

Participants

3

Reactant 2

HCID 5502061-(2-Furoyl)piperazineHCID 467010484-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Product 1

HCID 594023314-{7-[4-(2-Furoyl)piperazin-1-yl]-3,4-dihydroisoquinolin-2(1H)-yl}-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 30 starting from 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and 1-(2-furoyl)piperazine (Acros Organics, Cat. No. 23505). LCMS (M+H)+: m/z=503.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5062576ed6d04b8e87e8dbb00baff586
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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