Hydrochloric Acid → HCID 46701391, compound

Participants

Reaction Steps

tert-Butyl 4-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinolin-7-yl}piperazine-1-carboxylate (16 mg, 0.031 mmol) was treated with 4M HCl in dioxane (0.5 mL) at r.t. for 1 h. The reaction mixture was concentrated to dryness. 1-Chloro-4-isocyanatobenzene (5.0 uL, 0.041 mmol, Aldrich, Cat. No. 152277) was added to a mixture of above residue and triethylamine (22 uL, 0.16 mmol) in acetonitrile (1.0 mL). After stirring at r.t. for 2 h., the reaction mixture was diluted with MeOH and purified by RP-HPLC (pH=10 system) to afford the desired compound. LCMS(M+H)+: m/z=562.3.

Provenance & Evidence