Tert-butyl 3-oxopiperazine-1-carboxylate → HCID 59402287, compound

HRID 2090332Notes

Reaction equation

HRID 2090332 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([C:12]3[CH:17]=[C:16]([N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)[N:15]=[C:14]([NH2:25])[N:13]=3)[CH2:9]2)=[CH:4][CH:3]=1.[O:26]=[C:27]1[NH:32][CH2:31][CH2:30][N:29]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:28]1>>[NH2:25][C:14]1[N:13]=[C:12]([N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][C:2]([N:32]4[CH2:31][CH2:30][N:29]([C:33]([O:35][C:36]([CH3:38])([CH3:37])[CH3:39])=[O:34])[CH2:28][C:27]4=[O:26])=[CH:3][CH:4]=3)[CH2:9]2)[CH:17]=[C:16]([N:18]2[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]2)[N:15]=1

Participants

3

Reactant 2

HCID 3157178Tert-butyl 3-oxopiperazine-1-carboxylateHCID 467010484-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Product 1

HCID 59402287HCID 59402287, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 14 starting from 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and tert-butyl 3-oxopiperazine-1-carboxylate (Aldrich, Cat. No. 641057). LCMS (M+H)+: m/z=523.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-08c57fefc5cd4c61809b979ab0326f63
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

Loading…