Ethyl 6-chloronicotinate → HCID 59402385, compound

HRID 2090333Notes

Reaction equation

HRID 2090333 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][C:13]([N:19]4[CH2:24][CH2:23][NH:22][CH2:21][C:20]4=[O:25])=[CH:14][CH:15]=3)[CH2:10]2)[CH:6]=[C:5]([N:26]2[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]2)[N:4]=1.Cl[C:34]1[CH:44]=[CH:43][C:37]([C:38]([O:40][CH2:41][CH3:42])=[O:39])=[CH:36][N:35]=1>>[NH2:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][C:13]([N:19]4[CH2:24][CH2:23][N:22]([C:34]5[CH:44]=[CH:43][C:37]([C:38]([O:40][CH2:41][CH3:42])=[O:39])=[CH:36][N:35]=5)[CH2:21][C:20]4=[O:25])=[CH:14][CH:15]=3)[CH2:10]2)[CH:6]=[C:5]([N:26]2[CH2:27][CH2:28][N:29]([CH3:32])[CH2:30][CH2:31]2)[N:4]=1

Participants

3

Reactant 2

HCID 2799611Ethyl 6-chloronicotinateHCID 68471728HCID 68471728, compound

Product 1

HCID 59402385HCID 59402385, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 1, Step 2 starting from 1-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinolin-7-yl}piperazin-2-one hydrochloride and ethyl 6-chloronicotinate (Aldrich, Cat. No. 531197). LCMS (M+H)+: m/z=572.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-a96f7c56cb954893bd7d431ba310cd63
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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