HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-bromo-1,3-thiazole-4-carboxylate → tert-butyl 7-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-bromo-1,3-thiazole-4-carboxylate | HCID 353965 | — |
| Reactant | tert-Butyl 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 53302321 | — |
| Product | tert-butyl 7-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 59402277 | — |
Reaction Steps
This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from tert-butyl 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate and ethyl 2-bromo-1,3-thiazole-4-carboxylate (Combi-Blocks, Cat. No. HI-1116). LCMS (M+H)+: m/z=389.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436008B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-fa08986152bf459f8469a0717942f297 |
| Source note | uspto-grants-2013_05 |