反应详情

To a mixture of methyl [2-(4-bromophenyl)-1-methylethyl]carbamate (465 mg, 1.71 mmol) and paraformaldehyde (82.1 mg, 2.73 mmol) was added a mixture of concentrated sulfuric acid (2.5 mL, 47 mmol) and glacial acetic acid (3.75 mL, 66.0 mmol). The resulting mixture was stirred at r.t. overnight. The reaction mixture was poured into ice-water, and extracted with CH2Cl2. The organic layer was washed with water, saturated NaCO3 aqueous solution and brine, dried with MgSO4. After filtration, the filtrate was concentrated to afford the desired compound (490 mg, 100%) which was directly used in the next step reaction without further purification. LCMS (M+H)+: m/z=284.2.

1. additionwas added
2. extractionextracted with CH2Cl2
3. washThe organic layer was washed with water, saturated NaCO3 aqueous solution and brine
4. dry with materialdried with MgSO4
5. filtrationAfter filtration
6. concentrationthe filtrate was concentrated