2-Amino-4,6-dichloropyrimidine → 4-(7-bromo-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-6-chloropyrimidin-2-amine

HRID 2090343Notes

Reaction equation

HRID 2090343 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH:7]([CH3:12])[NH:8][CH2:9]2)=[CH:4][CH:3]=1.[NH2:13][C:14]1[N:19]=[C:18](Cl)[CH:17]=[C:16]([Cl:21])[N:15]=1>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH:7]([CH3:12])[N:8]([C:18]3[CH:17]=[C:16]([Cl:21])[N:15]=[C:14]([NH2:13])[N:19]=3)[CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 655222-Amino-4,6-dichloropyrimidineHCID 444054957-Bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 594023614-(7-bromo-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-6-chloropyrimidin-2-amine

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 1 starting from 7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline and 2-Amino-4,6-dichloropyrimidine (Alfa Aesar, Cat. No. A11330). LCMS (M+H)+: m/z=353.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-66c7d7eaeaed4082a187a40747a30006
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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