HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 4-[3-Methyl-7-{6-[(4-methylpiperazin-1-yl)carbonyl]pyridin-3-yl}-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 5-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyridine-2-carboxylic acid | HCID 59402360 | — |
| Product | 4-[3-Methyl-7-{6-[(4-methylpiperazin-1-yl)carbonyl]pyridin-3-yl}-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine | HCID 59402328 | — |
Reaction Steps
This compound was prepared by using procedures analogous to those described for the synthesis of Example 50A starting from 5-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyridine-2-carboxylic acid (Example 50A, Step 1) and 1-methylpiperazine (Aldrich, Cat. No. 130001). LCMS (M+H)+: m/z=542.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436008B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-9e5cfe666c854921800ccdbdea38410c |
| Source note | uspto-grants-2013_05 |