HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-pyrrolidin-3-ol → HCID 46701789, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-pyrrolidin-3-ol | HCID 2733874 | — |
| Reactant | 4-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyridine-2-carboxylic acid | HCID 59402335 | — |
| Product | HCID 46701789 | HCID 46701789 | — |
Reaction Steps
This compound was prepared by using procedures analogous to those described for the synthesis of Example 61A starting from 4-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyridine-2-carboxylic acid (Example 61A, Step 2) and (S)-(−)-3-Hydroxypyrrolidine (Fluka, Cat. No. 56437). LCMS (M+H)+: m/z=529.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436008B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-c180a0c7fa5d47a1bbc1beb668dd7d0b |
| Source note | uspto-grants-2013_05 |