Methanol → HCID 21921420, compound

HRID 2090380Notes

Reaction equation

HRID 2090380 reaction equation
[NH2:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].S(Cl)(Cl)=O.[CH3:18]O>>[NH2:1][CH:2]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([Br:13])=[CH:11][CH:12]=1)[C:3]([O:5][CH3:18])=[O:4]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 856814-Bromophenylalanine

Product 1

HCID 21921420HCID 21921420, compound

Procedure

To a solution of 2-amino-3-(4-bromophenyl)propanoic acid (2.0 g, 8.2 mmol, Chem-Impex, Cat. No. 06163) in methanol (10 mL) was added thionyl chloride (1.2 mL, 16 mmol) dropwise. The mixture was stirred at r.t. overnight and then concentrated under reduced pressure. The residue was washed with ether and dried under vacuum to afford the desired compound which was directly used in the next step reaction without further purification. LCMS (M+H)+: m/z=258.2.

Workup

  1. concentrationconcentrated under reduced pressure
  2. washThe residue was washed with ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-5bddd246c7ac40cb8c0f1c1761c12999
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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