3-(Dimethylamino)pyrrolidine → 4-[7-(5-{[3-(Dimethylamino)pyrrolidin-1-yl]carbonyl}-1-methyl-1H-pyrrol-3-yl)-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Participants

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 87A, Step 9 starting from 4-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}-1-methyl-1H-pyrrole-2-carboxylic acid (Example 87A, Step 8) and N,N-dimethylpyrrolidin-3-amine. LCMS (M+H)+: m/z=558.3.

Provenance & Evidence