反应详情

A mixture of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (50 mg, 0.2 mmol), 3-bromobutanenitrile (46 mg, 0.31 mmol, TCI America, Cat. No. B 1452), and cesium carbonate (250 mg, 0.77 mmol) in acetonitrile (1 mL) was stirred at 90° C. for 3 hours. After cooling it was quenched with water, extracted with ethyl acetate. The extract was washed with water twice, brine once; dried over Na2SO4. After filtration the filtrate was concentrated to yield 60 mg product. It was directly used in the next step reaction without further purification.

1. temperatureAfter cooling it
2. customwas quenched with water
3. extractionextracted with ethyl acetate
4. washThe extract was washed with water twice
5. dry with materialdried over Na2SO4
6. filtrationAfter filtration the filtrate
7. concentrationwas concentrated