Octahydropyrrolo(1,2-a)pyrazine → HCID 46701915, compound

HRID 2090464Notes

Reaction equation

HRID 2090464 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH:17]([CH3:18])[CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:19]4[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=4)=[CH:13][CH:14]=3)[CH2:9]2)[N:5]=[C:4]([NH2:25])[N:3]=1.[CH2:26]1[NH:31][CH2:30][CH2:29][N:28]2[CH2:32][CH2:33][CH2:34][CH:27]12>>[CH2:26]1[N:31]([C:2]2[CH:7]=[C:6]([N:8]3[CH:17]([CH3:18])[CH2:16][C:15]4[C:10](=[CH:11][C:12]([C:19]5[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=5)=[CH:13][CH:14]=4)[CH2:9]3)[N:5]=[C:4]([NH2:25])[N:3]=2)[CH2:30][CH2:29][N:28]2[CH2:32][CH2:33][CH2:34][CH:27]12

Participants

3

Reactant 2

HCID 558578Octahydropyrrolo(1,2-a)pyrazineHCID 59402369HCID 59402369, compound

Product 1

HCID 46701915HCID 46701915, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 118 starting from 4-chloro-6-[3-methyl-7-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine and octahydropyrrolo[1,2-a]pyrazine (Oakwood, Cat. No. 032034). LCMS (M+H)+: m/z=445.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-bee2922da17d41eab54854f7ce0de608
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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