HRID2090489

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70937

1-Pyrrolidinecarbonyl chloride

C5H8ClNO

结构：CC1Cc2ccc(C3CCNCC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.Cl

HCID68471086

未命名化合物

PRODUCTS

生成物

结构：CC1Cc2ccc(C3CCN(C(=O)N4CCCC4)CC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1

HCID59402298

未命名化合物

PROCEDURE

实验过程

This compound was prepared by using procedures analogous to those described for the synthesis of Example 138 starting from 4-(4-methylpiperazin-1-yl)-6-(3-methyl-7-piperidin-4-yl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine HCl salt and 1-pyrrolidinecarbonyl chloride. LCMS (M+H)+: m/z=519.2.

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e9948a75bc4342f8ba0a788bceba5cde
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436008B2
来源说明: uspto-grants-2013_05

反应 SMILES

Cl.[CH3:2][N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N:15]3[CH:24]([CH3:25])[CH2:23][C:22]4[C:17](=[CH:18][C:19]([CH:26]5[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]5)=[CH:20][CH:21]=4)[CH2:16]3)[N:12]=[C:11]([NH2:32])[N:10]=2)[CH2:5][CH2:4]1.[N:33]1([C:38](Cl)=[O:39])[CH2:37][CH2:36][CH2:35][CH2:34]1>>[CH3:2][N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N:15]3[CH:24]([CH3:25])[CH2:23][C:22]4[C:17](=[CH:18][C:19]([CH:26]5[CH2:27][CH2:28][N:29]([C:38]([N:33]6[CH2:37][CH2:36][CH2:35][CH2:34]6)=[O:39])[CH2:30][CH2:31]5)=[CH:20][CH:21]=4)[CH2:16]3)[N:12]=[C:11]([NH2:32])[N:10]=2)[CH2:5][CH2:4]1