1-Pyrrolidinecarbonyl chloride → 4-(4-Methylpiperazin-1-yl)-6-[3-methyl-7-[1-(pyrrolidin-1-ylcarbonyl)piperidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

HRID 2090489Notes

Reaction equation

HRID 2090489 reaction equation
Cl.[CH3:2][N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N:15]3[CH:24]([CH3:25])[CH2:23][C:22]4[C:17](=[CH:18][C:19]([CH:26]5[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]5)=[CH:20][CH:21]=4)[CH2:16]3)[N:12]=[C:11]([NH2:32])[N:10]=2)[CH2:5][CH2:4]1.[N:33]1([C:38](Cl)=[O:39])[CH2:37][CH2:36][CH2:35][CH2:34]1>>[CH3:2][N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N:15]3[CH:24]([CH3:25])[CH2:23][C:22]4[C:17](=[CH:18][C:19]([CH:26]5[CH2:27][CH2:28][N:29]([C:38]([N:33]6[CH2:37][CH2:36][CH2:35][CH2:34]6)=[O:39])[CH2:30][CH2:31]5)=[CH:20][CH:21]=4)[CH2:16]3)[N:12]=[C:11]([NH2:32])[N:10]=2)[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 709371-Pyrrolidinecarbonyl chlorideHCID 684710864-(4-Methylpiperazin-1-yl)-6-(3-methyl-7-piperidin-4-yl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 594022984-(4-Methylpiperazin-1-yl)-6-[3-methyl-7-[1-(pyrrolidin-1-ylcarbonyl)piperidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 138 starting from 4-(4-methylpiperazin-1-yl)-6-(3-methyl-7-piperidin-4-yl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine HCl salt and 1-pyrrolidinecarbonyl chloride. LCMS (M+H)+: m/z=519.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-e9948a75bc4342f8ba0a788bceba5cde
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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