2-Propanesulfonyl chloride → 4-[7-[1-(Isopropylsulfonyl)piperidin-4-yl]-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

HRID 2090490Notes

Reaction equation

HRID 2090490 reaction equation
Cl.[CH3:2][N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N:15]3[CH:24]([CH3:25])[CH2:23][C:22]4[C:17](=[CH:18][C:19]([CH:26]5[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]5)=[CH:20][CH:21]=4)[CH2:16]3)[N:12]=[C:11]([NH2:32])[N:10]=2)[CH2:5][CH2:4]1.[CH3:33][CH:34]([S:36](Cl)(=[O:38])=[O:37])[CH3:35]>>[CH:34]([S:36]([N:29]1[CH2:28][CH2:27][CH:26]([C:19]2[CH:18]=[C:17]3[C:22]([CH2:23][CH:24]([CH3:25])[N:15]([C:13]4[CH:14]=[C:9]([N:6]5[CH2:7][CH2:8][N:3]([CH3:2])[CH2:4][CH2:5]5)[N:10]=[C:11]([NH2:32])[N:12]=4)[CH2:16]3)=[CH:21][CH:20]=2)[CH2:31][CH2:30]1)(=[O:38])=[O:37])([CH3:35])[CH3:33]

Participants

3

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 684710864-(4-Methylpiperazin-1-yl)-6-(3-methyl-7-piperidin-4-yl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 594023054-[7-[1-(Isopropylsulfonyl)piperidin-4-yl]-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 138 starting from 4-(4-methylpiperazin-1-yl)-6-(3-methyl-7-piperidin-4-yl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine HCl salt and propane-2-sulfonyl chloride. LCMS (M+H)+: m/z=528.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-9e452ffe50f44021bb88680f25654ae5
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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