Methanesulfonyl chloride → HCID 59402275, compound

HRID 2090502Notes

Reaction equation

Cl.Cl.Cl.Cl.Cl.[CH3:6][N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[C:17]([N:19]3[CH:28]([CH3:29])[CH2:27][C:26]4[C:21](=[CH:22][C:23]([CH:30]5[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]5)=[CH:24][CH:25]=4)[CH2:20]3)[N:16]=[C:15]([NH2:36])[N:14]=2)[CH2:9][CH2:8]1.[CH3:37][S:38](Cl)(=[O:40])=[O:39]>>[CH3:29][CH:28]1[CH2:27][C:26]2[C:21](=[CH:22][C:23]([CH:30]3[CH2:31][CH2:32][N:33]([S:38]([CH3:37])(=[O:40])=[O:39])[CH2:34][CH2:35]3)=[CH:24][CH:25]=2)[CH2:20][N:19]1[C:17]1[CH:18]=[C:13]([N:10]2[CH2:11][CH2:12][N:7]([CH3:6])[CH2:8][CH2:9]2)[N:14]=[C:15]([NH2:36])[N:16]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 67435241HCID 67435241, compound

Product 1

HCID 59402275HCID 59402275, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 144 starting from 4-(4-methylpiperazin-1-yl)-6-(3-methyl-7-piperidin-4-yl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine tetrahydrochloride HCl salt (Example 144, Step 3) and methanesulfonyl chloride. LCMS (M+H)+: m/z=500.3.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-7fb4ef7fa38f45ffb1134151a3c515bf
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08436008B2

Reaction notes

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