Propionyl chloride → HCID 59402284, compound

HRID 2090503Notes

Reaction equation

Cl.Cl.Cl.Cl.Cl.[CH3:6][N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[C:17]([N:19]3[CH:28]([CH3:29])[CH2:27][C:26]4[C:21](=[CH:22][C:23]([CH:30]5[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]5)=[CH:24][CH:25]=4)[CH2:20]3)[N:16]=[C:15]([NH2:36])[N:14]=2)[CH2:9][CH2:8]1.[C:37](Cl)(=[O:40])[CH2:38][CH3:39]>>[CH3:6][N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[C:17]([N:19]3[CH:28]([CH3:29])[CH2:27][C:26]4[C:21](=[CH:22][C:23]([CH:30]5[CH2:31][CH2:32][N:33]([C:37](=[O:40])[CH2:38][CH3:39])[CH2:34][CH2:35]5)=[CH:24][CH:25]=4)[CH2:20]3)[N:16]=[C:15]([NH2:36])[N:14]=2)[CH2:9][CH2:8]1

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 67435241HCID 67435241, compound

Product 1

HCID 59402284HCID 59402284, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 144 starting from 4-(4-methylpiperazin-1-yl)-6-(3-methyl-7-piperidin-4-yl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine tetrahydrochloride HCl salt (Example 144, Step 3) and propanoyl chloride. LCMS (M+H)+: m/z=478.3.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-13b876126317480ea9439cac920a2e0f
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08436008B2

Reaction notes

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