3-Hydroxyazetidine hydrochloride → 1-[(4-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyridin-2-yl)carbonyl]azetidin-3-ol

Participants

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 61B starting from 4-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyridine-2-carboxylic acid (Example 61B, Step 2) and 3-hydroxyazetidine hydrochloride (Oakwood, Cat. No. 013898). LCMS (M+H)+: m/z=515.2.

Provenance & Evidence