HuagongsheHuagongshe Chemistry Print Report · For research reference only
(s)-3-Fluoropyrrolidine hydrochloride → HCID 59402321, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (s)-3-Fluoropyrrolidine hydrochloride | HCID 16217739 | — |
| Reactant | 5-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyridine-2-carboxylic acid | HCID 59402360 | — |
| Product | HCID 59402321 | HCID 59402321 | — |
Reaction Steps
This compound was prepared by using procedures analogous to those described for the synthesis of Example 50A starting from 5-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyridine-2-carboxylic acid (Example 50A, Step 1) and (S)-(+)-3-fluoropyrrolidine hydrochloride (Oakwood, Cat. No. 013157). LCMS (M+H)+: m/z=531.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436008B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-71d29cd019d44b97b256e027b5c50876 |
| Source note | uspto-grants-2013_05 |