Nitrogen → HCID 59402332, compound

Participants

Reaction Conditions

Reaction Steps

The residue was dissolved in 1,4-dioxane (0.50 mL) and water (0.10 mL). To the solution was added 4-(7-bromo-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine (0.018 g, 0.043 mmol, Peak 1, Example 49, Step 7), dichloro(bis{di-tert-butyl[4-(dimethylamino)phenyl]phosphoranyl})palladium (0.916 mg, 0.00129 mmol), sodium carbonate (9.14 mg, 0.0862 mmol). and the mixture was vacuumed and refilled with N2 for 3 times. The reaction was stirred at 90° C. overnight. The mixture was purified by RP-HPLC (pH=10) to afford the desired product. LCMS (M+H)+: m/z=496.3.

Provenance & Evidence