Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Bromoacetophenone → 1-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)butane-1,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Bromoacetophenone | HCID 7466 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Benzeneacetic acid, 3,4-dimethoxy-, methyl ester | HCID 85213 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)butane-1,3-dione | HCID 59188720 | 50.1% |
반응 단계
Sodium hydride (60% dispersion, 3.80 g, 95.1 mmol) was added portionwise to methyl 2-(3,4-dimethoxyphenyl)acetate (10 g, 47.6 mmol) in Et2O (100 ml) at 0° C. A solution of 4′-bromoacetophenone (9.48 g, 47.6 mmol) in Et2O (50 ml) was added dropwise over 1 h. The mixture was heated at reflux for 16 h, cooled, poured into ice/HCl (2 M), extracted with Et2O (3×100 ml), dried (MgSO4) and the solvent removed under reduced pressure. The residue was crystallized from MeOH to give the title compound (9 g, 50%) as a tan powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08436184B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-8a89e9ab370b4e7eb95f337133cf722e |
| 출처 메모 | uspto-grants-2013_05 |