Fumaric Acid → HCID 68771419, compound

Participants

Reaction Conditions

Reaction Steps

50 mg of tert-butyl(3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate (Example 1, D3) as a compound stock solution was reacted with 1 mole equivalent of fumaric acid, added as a 0.405 Molar solution in ethanol. Excess solvent was removed under centrifugal evaporation and 1 mL of ethanol added at ambient room temperature (˜25° C.). The resultant solution stirred at 40° C. for 24 hours. The experiment was left to gently evaporate under atmospheric conditions where a colorless solid was observed. This solid was analyzed using x-ray powder diffraction, proton NMR, DSC and TGA to confirm the formation of the title salt.

Provenance & Evidence