Hydrochloric Acid → HCID 66725981, compound

Participants

Reaction Steps

To a solution of 2-azido-1-(3-(4-(2-azidoacetyl)phenoxy)phenyl)ethanone (9 g, 26.4 mmol) in methanol (400 mL) was added HCl (1M in methanol, 53 mL) and the mixture was hydrogenated using Pd/C (10%) under hydrogen atmosphere (1 bar) during 2 hours. The solution was filtered over celite and concentrated under reduced pressure. The crude was dissolved in dichloromethane and after addition of HCl (6N in isopropanol) the hydrochloride salt precipitated. Filtration and drying in vacuo afforded 2-amino-1-(3-(4-(2-aminoacetyl)phenoxy)phenyl)ethanone dihydrochloride.

Provenance & Evidence