HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 178425017, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | m-Tolylacetic acid | HCID 12121 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 178478256 | HCID 178478256 | — |
| Product | HCID 178425017 | HCID 178425017 | — |
Reaction Steps
To a solution of 2-((S)-pyrrolidin-2-yl)-5-(4-(3-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)phenoxy)phenyl)-1H-imidazole hydrochloride (100 mg, 0.22 mmol) in DMF (22 mL) was added N,N-diisopropylethylamine (0.2 mL), HATU (216 mg, 0.56 mmol) and 2-m-tolyl acetic acid (75 mg, 0.5 mmol). The reaction was stirred for 1 hour at room temperature and concentrated under reduced pressure. The crude product was purified by reverse-phase preparative HPLC to provide 2-m-tolyl-1-((2S)-2-(5-(4-(3-(2-((S)-1-(2-m-tolylacetyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)phenoxy)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)ethanone (5 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436036B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-7b6b3585289e454e9d6dcf228e0f0418 |
| Source note | uspto-grants-2013_05 |