HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2090580Generated: November 3, 2026
Acetic Acid → Benzoic acid, 4-hydroxy-, carboxymethyl ester
https://huagongshe.com/reaction/2090580
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 4-Hydroxy-benzoic acid tert-butoxycarbonylmethyl ester | HCID 58427509 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Benzoic acid, 4-hydroxy-, carboxymethyl ester | HCID 58427513 | — |
Reaction Steps
To a solution of 4-hydroxy-benzoic acid tert-butoxycarbonylmethyl ester 15 (18 grams, 71.42 mmol) in tetrahydrofuran (100 mL) is added 10% lithium hydroxide solution (35 mL). The mixture is heated at 50-60° C. for 1 hour. The reaction mass is cooled to room temperature, and the pH is adjusted to 4 with dilute acetic acid. The organic phase is separated and distilled to give crude 16, which can be purified in appropriate solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08436201B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-00123eb356ef416fa6290c381e57c6d0 |
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| Source note | uspto-grants-2013_05 |
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