Trifluoroacetic acid → HCID 58246486, compound

Participants

Reaction Steps

250 mg (0.42 mmol) of tert-butyl ((S)-1-(3H-imidazol-4-ylmethyl)-2-oxo-2-{4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-piperidin-1-yl}ethyl)carbamate are dissolved in 20 ml of dichloromethane and 1 ml of trifluoroacetic acid and stirred at room temperature for 12 h. The reaction mixture is washed with 0.1 N NaOH, the organic phase is dried over sodium sulfate and purified by column chromatography on silica gel. The crude product is dissolved in acetone, and a pH of 4 is set using 1 N HCl. A white precipitate forms in the process, which is filtered off with suction, washed with ether and dried in vacuo. Yield: 200 mg of “A63” hydrochloride, white solid; ESI: 492 (M+H).

Provenance & Evidence