Methyl acetoacetate → HCID 178498883, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl acetoacetate (30.0 g) and dimethylformamide dimethylacetal (34.7 mL) was stirred at 100° C. for 12 hr, and the mixture was allowed to cool. Ethanol (500 mL) and hydrazine monohydrate (12.6 mL) were added to the reaction mixture at room temperature, and the mixture was heated under reflux for 12 hr. The mixture was allowed to cool, and concentrated under reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. The extract was concentrated under reduced pressure to give the title object compound (22.3 g, 61%) as a pale-yellow solid.

Provenance & Evidence