Hydrazine hydrate (1:1) → HCID 178498886, compound

Participants

Reaction Steps

Using methyl 4-methyl-3-oxopentanoate (2.9 g), dimethylformamide dimethylacetal (2.8 mL) and hydrazine monohydrate (1.1 mL) and in the same manner as in Example 1(3), a crude product of methyl 3-(1-methylethyl)-1H-pyrazole-4-carboxylate was obtained. This was dissolved in dimethylformamide (30 ml), potassium carbonate (4.2 g) and 2-chloro-5-trifluoromethylpyridine (3.6 g) were added, and the mixture was stirred at 100° C. for 2 hr. In the same manner as in an Example 1(4), the title object compound (4.6 g, 73%) was obtained as a white solid.

Provenance & Evidence