Ethyl 3-(4-aminobenzamido)propanoate → HCID 66777890, compound

HRID 2090842Notes

Reaction equation

HRID 2090842 reaction equation
[CH:1]1([CH:7]([C:9]2[C:10]([CH:24]3[CH2:26][CH2:25]3)=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=3)[CH:13]=2)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]([NH:36][CH2:37][CH2:38][C:39]([O:41]CC)=[O:40])=[O:35])=[CH:30][CH:29]=1>>[CH:1]1([CH:7]([NH:27][C:28]2[CH:29]=[CH:30][C:31]([C:34]([NH:36][CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:35])=[CH:32][CH:33]=2)[C:9]2[C:10]([CH:24]3[CH2:26][CH2:25]3)=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=3)[CH:13]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777934HCID 66777934, compound

Product 1

HCID 66777890HCID 66777890, compoundYield 21%

Procedure

Using cyclohexyl{3-cyclopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}methanol (0.50 g) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (0.32 g) synthesized in Example 1(2) and in the same manner as in Example 1(7), the title object compound (0.15 g, 21%) was obtained as a white solid.

Sources & evidence

ORD record
ord-2e4f2735b2a340cc90c45efb8fe805b3
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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