Ethyl 3-(4-aminobenzamido)propanoate → HCID 66777515, compound

HRID 2090845Notes

Reaction equation

HRID 2090845 reaction equation
[CH:1]1([CH:7]([C:9]2[C:10]([CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=3)[CH:13]=2)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:32][C:33]1[CH:38]=[CH:37][C:36]([C:39]([NH:41][CH2:42][CH2:43][C:44]([O:46]CC)=[O:45])=[O:40])=[CH:35][CH:34]=1>>[CH:1]1([CH:7]([NH:32][C:33]2[CH:34]=[CH:35][C:36]([C:39]([NH:41][CH2:42][CH2:43][C:44]([OH:46])=[O:45])=[O:40])=[CH:37][CH:38]=2)[C:9]2[C:10]([CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:22])([F:21])[F:23])=[CH:16][N:15]=3)[CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66778467HCID 66778467, compound

Product 1

HCID 66777515HCID 66777515, compoundYield 28%

Procedure

Using cyclohexyl{3-(2-phenylethyl)-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}methanol (0.50 g) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (0.28 g) synthesized in Example 1(2) and in the same manner as in Example 1(7), the title object compound (0.20 g, 28%) was obtained as a white solid.

Sources & evidence

ORD record
ord-5a4ce0e217f549be82dd4887fd093334
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

Loading…