Ethyl 3-(4-aminobenzamido)propanoate → HCID 66777876, compound

HRID 2090848Notes

Reaction equation

HRID 2090848 reaction equation
[CH:1]1([CH:7]([C:9]2[C:10]([C:24]([CH3:27])([CH3:26])[CH3:25])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=3)[CH:13]=2)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]([NH:37][CH2:38][CH2:39][C:40]([O:42]CC)=[O:41])=[O:36])=[CH:31][CH:30]=1>>[C:24]([C:10]1[C:9]([CH:7]([NH:28][C:29]2[CH:30]=[CH:31][C:32]([C:35]([NH:37][CH2:38][CH2:39][C:40]([OH:42])=[O:41])=[O:36])=[CH:33][CH:34]=2)[CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:13][N:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:16][N:15]=2)[N:11]=1)([CH3:25])([CH3:26])[CH3:27]

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777704HCID 66777704, compound

Product 1

HCID 66777876HCID 66777876, compoundYield 15.5%

Procedure

Using cyclohexyl{3-tert-butyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}methanol (0.53 g) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (0.32 g) synthesized in Example 1(2) and in the same manner as in Example 1(7), the title object compound (0.12 g, 15%) was obtained as a white solid.

Sources & evidence

ORD record
ord-6f92a62b2e4349b9b719d760b47b493f
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

Loading…