4-Chlorophenylboronic acid → HCID 66778803, compound

HRID 2090856Notes

Reaction equation

HRID 2090856 reaction equation
[CH3:1][C:2]1[C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][NH:4][N:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>C([O-])(=O)C.[Cu+2].C([O-])(=O)C.N1C=CC=CC=1>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:4]2[CH:5]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[C:2]([CH3:1])=[N:3]2)=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 178498883HCID 178498883, compound

Product 1

HCID 66778803HCID 66778803, compoundYield 62%

Reagents, catalysts & solvents 2

HCID 8895Cupric acetateCatalystHCID 1049PyridineSolvent

Procedure

Using methyl 3-methyl-1H-pyrazole-4-carboxylate (6.25 g) synthesized in Example 1(3), 4-chlorophenylboronic acid (13.9 g), copper acetate (16.3 g) and pyridine (14.4 mL), and in the same manner as in Example 17(1), the title object compound (6.9 g, 62%) was obtained as a white solid.

Sources & evidence

ORD record
ord-21be896e29c8402c8627d436a824ea39
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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