Ethyl 3-(4-aminobenzamido)propanoate → HCID 66778684, compound

HRID 2090857Notes

Reaction equation

HRID 2090857 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH:13]([CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)O)[C:10]([CH3:21])=[N:9]2)=[CH:4][CH:3]=1.[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([NH:31][CH2:32][CH2:33][C:34]([O:36]CC)=[O:35])=[O:30])=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH:13]([NH:22][C:23]3[CH:24]=[CH:25][C:26]([C:29]([NH:31][CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[O:30])=[CH:27][CH:28]=3)[CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C:10]([CH3:21])=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777108HCID 66777108, compound

Product 1

HCID 66778684HCID 66778684, compoundYield 57.3%

Procedure

Using [1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl](cyclohexyl)methanol (0.46 g) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (0.35 g) synthesized in Example 1(2) and in the same manner as in Example 1(7), the title object compound (0.42 g, 57%) was obtained as a white solid.

Sources & evidence

ORD record
ord-b34f484540e44b4a84c51ffd7dfa4b4b
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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