Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66778113, compound

HRID 2090861Notes

Reaction equation

HRID 2090861 reaction equation
[CH:1]1([CH:7]([C:9]2[C:10]([CH3:22])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[CH3:21])[CH:13]=2)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([N:32]([CH3:40])[CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])=[O:31])=[CH:26][CH:25]=1>>[F:20][C:17]1[CH:18]=[CH:19][C:14]([N:12]2[CH:13]=[C:9]([CH:7]([NH:23][C:24]3[CH:25]=[CH:26][C:27]([C:30]([N:32]([CH3:40])[CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[O:31])=[CH:28][CH:29]=3)[CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[C:10]([CH3:22])=[N:11]2)=[C:15]([CH3:21])[CH:16]=1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66777264HCID 66777264, compound

Product 1

HCID 66778113HCID 66778113, compoundYield 60.8%

Procedure

Using cyclohexyl[1-(4-fluoro-2-methylphenyl)-3-methyl-1H-pyrazol-4-yl]methanol (0.50 g) synthesized in Example 21(3) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (0.39 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (0.48 g, 60%) was obtained as a white solid.

Sources & evidence

ORD record
ord-0ed3b7a88ad24bd58db6dd3a3ad77b5b
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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