Hydrazine hydrate (1:1) → HCID 178494719, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-methoxyacetoacetate (25.0 g) and dimethylformamide dimethylacetal (22.9 mL) was stirred at 100° C. for 2 hr, and the mixture was allowed to cool to room temperature. To the reaction mixture were added ethanol (250 mL) and hydrazine monohydrate (8.3 mL), and the mixture was heated under reflux for 12 hr. After allowing to cool, the reaction mixture was concentrated under reduced pressure, and water was added to the residue. The mixture was extracted with ethyl acetate to give a crude product (25.08 g) of methyl 3-methoxymethyl)-1H-pyrazole-4-carboxylate as a pale-yellow solid. The present compound was directly used for the next reaction.

Provenance & Evidence