2-Chloro-5-(trifluoromethyl)pyridine → HCID 66777926, compound

HRID 2090872Notes

Reaction equation

HRID 2090872 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][NH:6][N:5]=1.Cl[C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=1>>[CH3:1][O:2][CH2:3][C:4]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][N:6]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=2)[N:5]=1

Participants

3

Reactant 2

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 178494719HCID 178494719, compound

Product 1

HCID 66777926HCID 66777926, compoundYield 51.6%

Procedure

Using methyl 3-(methoxymethyl)-1H-pyrazole-4-carboxylate (7.4 g) synthesized above and 2-chloro-5-trifluoromethylpyridine (5.8 g) and in the same manner as in Example 1(4), the title object compound (5.2 g, 38%) was obtained as a white solid.

Sources & evidence

ORD record
ord-740c0ad2db8a4dd9899d62625aad051b
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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