Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66778176, compound

HRID 2090874Notes

Reaction equation

HRID 2090874 reaction equation
[CH:1]1([CH:7]([C:9]2[C:10]([CH2:24][O:25][CH3:26])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=3)[CH:13]=2)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]([N:36]([CH3:44])[CH2:37][CH2:38][C:39]([O:41]CC)=[O:40])=[O:35])=[CH:30][CH:29]=1>>[CH:1]1([CH:7]([NH:27][C:28]2[CH:29]=[CH:30][C:31]([C:34]([N:36]([CH3:44])[CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:35])=[CH:32][CH:33]=2)[C:9]2[C:10]([CH2:24][O:25][CH3:26])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=3)[CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66778625HCID 66778625, compound

Product 1

HCID 66778176HCID 66778176, compoundYield 9.1%

Procedure

Using cyclohexyl{3-(methoxymethyl)-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}methanol (1.2 g) synthesized in Example 29(4) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (1.0 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (0.17 g, 8%) was obtained as a white solid.

Sources & evidence

ORD record
ord-37e79e91eb164c6d8c76bbccf38a8587
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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