Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66777296, compound

HRID 2090878Notes

Reaction equation

HRID 2090878 reaction equation
[Cl:1][C:2]1[C:3]([N:12]2[CH:16]=[C:15]([CH:17]([CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)O)[C:14]([CH3:25])=[N:13]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[NH2:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([N:35]([CH3:43])[CH2:36][CH2:37][C:38]([O:40]CC)=[O:39])=[O:34])=[CH:29][CH:28]=1>>[Cl:1][C:2]1[C:3]([N:12]2[CH:16]=[C:15]([CH:17]([NH:26][C:27]3[CH:28]=[CH:29][C:30]([C:33]([N:35]([CH3:43])[CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[O:34])=[CH:31][CH:32]=3)[CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[C:14]([CH3:25])=[N:13]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66778241HCID 66778241, compound

Product 1

HCID 66777296HCID 66777296, compoundYield 5%

Procedure

Using {1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-3-methyl-1H-pyrazol-4-yl}(cyclohexyl)methanol (0.74 g) synthesized in Example 31(3) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (0.60 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (54.4 mg, 5%) was obtained as an amorphous pale-yellow solid.

Sources & evidence

ORD record
ord-b67fe984beae4ba69ca900d9dae9106a
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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