Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66778997, compound

HRID 2090883Notes

Reaction equation

HRID 2090883 reaction equation
[CH:1]1([CH:7]([C:9]2[C:10]([CH2:22][O:23][CH3:24])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[CH:13]=2)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([N:34]([CH3:42])[CH2:35][CH2:36][C:37]([O:39]CC)=[O:38])=[O:33])=[CH:28][CH:27]=1>>[CH:1]1([CH:7]([NH:25][C:26]2[CH:27]=[CH:28][C:29]([C:32]([N:34]([CH3:42])[CH2:35][CH2:36][C:37]([OH:39])=[O:38])=[O:33])=[CH:30][CH:31]=2)[C:9]2[C:10]([CH2:22][O:23][CH3:24])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66777067HCID 66777067, compound

Product 1

HCID 66778997HCID 66778997, compoundYield 36.3%

Procedure

Using cyclohexyl[3-(methoxymethyl)-1-(4-methoxyphenyl)-1H-pyrazol-4-yl]methanol (0.75 g) synthesized in Example 35(3) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (0.57 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (0.44 g, 36%) was obtained as a white solid.

Sources & evidence

ORD record
ord-67a2361cbea44a5da1845c40d7146040
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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