Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66778761, compound

HRID 2090896Notes

Reaction equation

HRID 2090896 reaction equation
[CH:1]1([C:4]2[C:8]([CH:9](O)[CH2:10][CH:11]([CH3:13])[CH3:12])=[CH:7][N:6]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[N:5]=2)[CH2:3][CH2:2]1.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([N:32]([CH3:40])[CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])=[O:31])=[CH:26][CH:25]=1>>[CH:1]1([C:4]2[C:8]([CH:9]([NH:23][C:24]3[CH:25]=[CH:26][C:27]([C:30]([N:32]([CH3:40])[CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[O:31])=[CH:28][CH:29]=3)[CH2:10][CH:11]([CH3:13])[CH3:12])=[CH:7][N:6]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[N:5]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 667772971-[3-cyclopropyl-1-(4-methoxyphenyl)-1H-pyrazol-4-yl]-3-methylbutan-1-ol

Product 1

HCID 66778761HCID 66778761, compoundYield 12%

Procedure

Using 1-[3-cyclopropyl-1-(4-methoxyphenyl)-1H-pyrazol-4-yl]-3-methylbutan-1-ol (0.5 g) synthesized in Example 44(3) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (0.33 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (80 mg, 9%) was obtained as a white solid.

Sources & evidence

ORD record
ord-a54f8bd484414a169024b251555e5249
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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