Ethyl 3-(4-aminobenzamido)propanoate → HCID 66777752, compound

HRID 2090900Notes

Reaction equation

HRID 2090900 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:10][CH2:11][CH2:12][C:13]([O:15]CC)=[O:14])=[O:9])=[CH:4][CH:3]=1.[CH2:18]([C:20]1[C:24]([CH:25](O)[CH2:26][CH:27]([CH3:29])[CH3:28])=[CH:23][N:22]([C:31]2[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=2)[N:21]=1)[CH3:19]>>[CH2:18]([C:20]1[C:24]([CH:25]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]([NH:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[O:9])=[CH:6][CH:7]=2)[CH2:26][CH:27]([CH3:29])[CH3:28])=[CH:23][N:22]([C:31]2[CH:32]=[CH:33][C:34]([O:37][CH3:38])=[CH:35][CH:36]=2)[N:21]=1)[CH3:19]

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66778620HCID 66778620, compound

Product 1

HCID 66777752HCID 66777752, compoundYield 25%

Procedure

Using in 1-[3-ethyl-1-(4-methoxyphenyl)-1H-pyrazol-4-yl]-3-methylbutan-1-ol (0.5 g) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (0.41 g) synthesized in Example 1(2) and in the same manner as in Example 1(7), the title object compound (0.2 g, 25%) was obtained as a white solid.

Sources & evidence

ORD record
ord-ee824256fbc840b89baf4251930484d2
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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