Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66779304, compound

HRID 2090908Notes

Reaction equation

HRID 2090908 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[C:12]([CH:14](O)[CH2:15][CH:16]([CH3:18])[CH3:17])[C:11]([CH:20]([CH3:22])[CH3:21])=[N:10]2)=[CH:5][CH:4]=1.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([N:32]([CH3:40])[CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])=[O:31])=[CH:26][CH:25]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[C:12]([CH:14]([NH:23][C:24]3[CH:25]=[CH:26][C:27]([C:30]([N:32]([CH3:40])[CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[O:31])=[CH:28][CH:29]=3)[CH2:15][CH:16]([CH3:18])[CH3:17])[C:11]([CH:20]([CH3:22])[CH3:21])=[N:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66777255HCID 66777255, compound

Product 1

HCID 66779304HCID 66779304, compoundYield 1%

Procedure

Using 1-[(1-(4-methoxyphenyl)-3-(1-methylethyl)-1H-pyrazol-4-yl]-3-methylbutan-1-ol (0.57 g) synthesized in Example 54(1) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (0.48 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (8.0 mg, 1%) was obtained as a white solid.

Sources & evidence

ORD record
ord-fcfc81b06f134272a6c421efbe81fe6b
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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