HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-5-carbaldehyde → 1-{1-ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}-3-methylbutan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-5-carbaldehyde | HCID 86662718 | — |
| Reactant | HCID 178420648 | HCID 178420648 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-{1-ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}-3-methylbutan-1-ol | HCID 68629236 | 31% |
Reaction Steps
1-Ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-5-carbaldehyde (2.5 g) synthesized in Example 58(2) was dissolved in tetrahydrofuran (20 mL), and 1M isobutylmagnesium bromide tetrahydrofuran solution (12 mL) was added dropwise at 0° C. In the same manner as in Example 1(6), the title object compound (0.9 g, 31%) was obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436043B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-06434d69a2f74ff2847ba00e22ff65c6 |
| Source note | uspto-grants-2013_05 |