Ethyl 3-(4-aminobenzamido)propanoate → HCID 66778624, compound

HRID 2090915Notes

Reaction equation

HRID 2090915 reaction equation
[CH2:1]([O:8][C:9]1[C:13]([CH:14]([CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)O)=[CH:12][N:11]([C:22]2[CH:27]=[CH:26][C:25]([O:28][C:29]([F:32])([F:31])[F:30])=[CH:24][CH:23]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]([NH:42][CH2:43][CH2:44][C:45]([O:47]CC)=[O:46])=[O:41])=[CH:36][CH:35]=1>>[CH2:1]([O:8][C:9]1[C:13]([CH:14]([NH:33][C:34]2[CH:35]=[CH:36][C:37]([C:40]([NH:42][CH2:43][CH2:44][C:45]([OH:47])=[O:46])=[O:41])=[CH:38][CH:39]=2)[CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)=[CH:12][N:11]([C:22]2[CH:27]=[CH:26][C:25]([O:28][C:29]([F:31])([F:32])[F:30])=[CH:24][CH:23]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777400HCID 66777400, compound

Product 1

HCID 66778624HCID 66778624, compoundYield 56%

Procedure

Using {3-(benzyloxy)-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl}(cyclohexyl)methanol (0.50 g) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (0.26 g) synthesized in Example 1(2) and in the same manner as in Example 1(7), the title object compound (0.39 g, 56%) was obtained as a white solid.

Sources & evidence

ORD record
ord-f818ad3ea6044fc68c8e8789a1b1c949
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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